Biologics from China
Reported on 8 March by Eric Palmer from Fierce Pharma, 2018 marks a landmark event in the global biologics supply chain—for the first time, an FDA approved biologic will be…
0 Comments
August 15, 2018
Can a Sugar High be a Problem in Cell Culture? You Betcha!
You may be aware of the diagnostic value of hemoglobin A1C in managing patients who are at risk of developing diabetes. Hemoglobin A1C is glycated hemoglobin that results from the…
July 31, 2018
Boosting Protein Yield in CHO Culture
Cell growth and product expression are key operating parameters in the manufacture of biologics from CHO cells. Chemical additives such as sodium butyrate have been used to enhance product expression. …
July 2, 2018
Antibody Drug Conjugates: Converting Antibodies into Therapeutic Guided Missiles
We report on antibody drug conjugates, another exciting drug class that is proving to be an important tool in the fight against cancer. Leukemias, lymphomas, and myelomas are among the…
June 12, 2018
Monoclonal antibody (mAb or moAb), made by identical immune cells that are all clones of a unique parent cell. Most biotech drugs are monoclonal antibodies
Antibodies to watch in 2018
We have reported before on the annual preview of mAb products published by the journal mAbs at the start of each new year. For 2018, Hélène Kaplon & Janice M.…
March 6, 2018
More fun with bispecific antibodies!
The eagerly awaited Part 2 of our review of bispecific antibodies (bsAbs) entitled “Therapeutic IgG-Like Bispecific Antibodies-Modular Versatility and Manufacturing” appears in the January 2018 issue of BioProcess International. In…
February 22, 2018
Therapeutic Fc Fusion Proteins to Watch
At Chamow & Associates we have an ongoing interest in therapeutic Fc-fusion proteins. We have published recently on the subject (A. Linderholm and S.M. Chamow, Immunoglobulin Fusion Proteins, Parts 1…
February 12, 2018
How Good are Assays for Host Cell Impurities?
Bioprocesses used to produce recombinant proteins are based on the growth and expansion of living cells in bioreactors. Using the tools of genetic engineering, scientists modify living cells, usually Chinese…
January 22, 2018
Dr. Chamow at PEPTALK 2018
Dr. Chamow is presenting at the PEPTALK 2018 conference in San Diego this week (Jan 8). His presentation is entitled “Making proteins “druggable”: Fc fusion proteins as a therapeutic class”. …
January 8, 2018
Cutting mAbs with precision: GingisKHAN™
As multivalent antibodies find their way to the therapeutics market, the ability to evaluate affinity and avidity becomes a key step to their success. Separating individual binding units by cutting…
January 8, 2018