Biologics from China

Reported on 8 March by Eric Palmer from Fierce Pharma, 2018 marks a landmark event in the global biologics supply chain—for the first time, an FDA approved biologic will be…

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Boosting Protein Yield in CHO Culture

Cell growth and product expression are key operating parameters in the manufacture of biologics from CHO cells.  Chemical additives such as sodium butyrate have been used to enhance product expression. …

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Antibodies to watch in 2018
Monoclonal antibody (mAb or moAb), made by identical immune cells that are all clones of a unique parent cell. Most biotech drugs are monoclonal antibodies

Antibodies to watch in 2018

We have reported before on the annual preview of mAb products published by the journal mAbs at the start of each new year. For 2018, Hélène Kaplon & Janice M.…

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More fun with bispecific antibodies!

The eagerly awaited Part 2 of our review of bispecific antibodies (bsAbs) entitled “Therapeutic IgG-Like Bispecific Antibodies-Modular Versatility and Manufacturing” appears in the January 2018 issue of BioProcess International. In…

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Therapeutic Fc Fusion Proteins to Watch

At Chamow & Associates we have an ongoing interest in therapeutic Fc-fusion proteins.  We have published recently on the subject (A. Linderholm and S.M. Chamow, Immunoglobulin Fusion Proteins, Parts 1…

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How Good are Assays for Host Cell Impurities?

Bioprocesses used to produce recombinant proteins are based on the growth and expansion of living cells in bioreactors. Using the tools of genetic engineering, scientists modify living cells, usually Chinese…

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Dr. Chamow at PEPTALK 2018

Dr. Chamow is presenting at the PEPTALK 2018 conference in San Diego this week (Jan 8).  His presentation is entitled “Making proteins “druggable”:  Fc fusion proteins as a therapeutic class”. …

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Cutting mAbs with precision: GingisKHAN™

As multivalent antibodies find their way to the therapeutics market, the ability to evaluate affinity and avidity becomes a key step to their success.  Separating individual binding units by cutting…

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